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                        P

                        PRODUCTS

                        PRODUCTS

                        Florfenicol Powder

                        GMP acceptance of veterinary drugs passed the enterprise

                        Veterinary drug GMP Certificate Number: (2022) Veterinary drug GMP Certificate number 15049

                        Veterinary drug production Certificate Number: (2022) Veterinary drug production Certificate number 15318

                         

                        Instructions For Florfenicol Powder 

                        (Veterinary prescription drugs)

                         

                        【Veterinary drug name】

                        Product Name: Florfenicol powder

                        Chinese Pinyin: Fubennikao Fen

                        【Main ingredient】 Florfenicol

                        【Characters】This product is white or white-like powder.

                        【Pharmacological action】 

                        Pharmacodynamics Florfenicol is a broad spectrum antibiotic in the amidol class, a bacteriosuppressor, which acts by binding with the ribosome 50S subunit to inhibit the synthesis of bacterial proteins. It has strong antibacterial activity against a variety of gram-positive and Gram-negative bacteria. Pasteurella hemolyticus, Pasteurella multocida and actinobacillus pleuropneumoniae were highly sensitive to florfenicol. In vitro, the antimicrobial activity of florfenicol against many microorganisms is similar or stronger than that of sulfenicol, and some bacteria that are resistant to aminools due to acetylation, such as Escherichia coli and Klebsiella pneumoniae, may still be sensitive to florfenicol.

                        It is mainly used for the bacterial diseases of pigs, chickens and fish caused by sensitive bacteria, such as Pasteurella hemolyticus, Pasteurella multocida and actinobacillus pleuropneumoniae caused by bovine and pig respiratory diseases. Typhoid fever and paratyphoid fever caused by salmonella, chicken cholera, chicken white dysentery, escherichia coli, etc. Fish Pasteurella, Vibrio, staphylococcus aureus, hydroomonas, enteritis and other bacteria caused by fish bacterial septicemia, enteritis, erythroderma and so on.

                        Pharmacokinetics The absorption of florfenicol is rapid, and the therapeutic concentration can be reached in the blood after about 1 hour, and the peak blood concentration can be reached in 1 to 3 hours. The bioavailability is over 80%. Florfenicol is widely distributed in animals and can cross the blood-brain barrier. It is mainly excreted in the urine in its original form, and a small amount is excreted in the stool.

                        【Drug interaction】

                        (1)Macrolides and Lincoamines have the same target as this product, they are bound to the bacterial ribosome 50S subunit, and can produce antagonistic effects when combined.

                        (2)May antagonize the bactericidal activity of penicillins or aminoglycosides, but       has not been demonstrated in animals.

                        【Action and use】

                        Amidol antibiotics. For Pasteurella and Escherichia coliinfections.

                        【Usage and dosage】 

                        Calculated with this product. Oral administration:

                        0.2~0.3g for pig and chicken per 1kg body weight, twice a day, 3-5days consecutive days.

                        【Untoward effect】

                        This product has a certain immunosuppressive effect when used at higher than the recommended dose.

                        【Cautions】

                        (1) Chickens that lay eggs for human consumption shall not be used during the laying period.

                        (2) Breeding chickens should be used with caution. It is toxic to embryos and should be used with caution during pregnancy and lactation.

                        (3) Animals with severe immune function impairment or vaccination period are prohibited.

                        (4) Animals with renal insufficiency should be appropriately reduced or extended administration interval time.

                        【Drug withdrawal period】Pig 20 days, chicken 5 days, fish 375 days.

                        【Specification】10 % 

                        【 Package 】 500g/ bag×30 bags/box, 100g/ bag×120 bags/box

                        【 Storage 】 Sealed and stored in a dry place.

                        【Approval number】 Veterinary Drug 153182110

                        【Production date】

                        【Batch number】

                        【Validity until】

                        【Manufacturer】

                        Shandong Dexin Biotechnology Co., Ltd

                        Add: Xindian Industrial Park, Huimin County, Shandong Province

                        Zip code: 251700               Tel: 0543-5057789               Fax: 0543-5760099

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